While NSAIDs and Tylenol are generally safe when used as directed, they can pose risks to the liver and kidneys, especially with prolonged use or in high doses. NSAIDs can cause kidney damage, particularly in individuals with pre-existing kidney conditions or those who are dehydrated. Tylenol, when taken in excessive amounts or combined with alcohol, can lead to liver toxicity and potentially life-threatening liver failure. It’s essential to use these medications cautiously, follow recommended dosages, and consult with a healthcare provider if you have any concerns about their safety, especially if you have underlying liver or kidney issues.